
Cruz has been awarded three Goyas, two European Film Awards, and the Best Actress Award at the Cannes Film Festival. In 2009, she won an Academy Award for Best Supporting Actress, a Goya, and a BAFTA for her role in Vicky Cristina Barcelona. She is Spain's first female Oscar winner and also becomes the sixth Hispanic person to win an Oscar after José Ferrer, Rita Moreno, Benicio Del Toro (Puerto Rico), Anthony Quinn (Mexico), and fellow Spaniard Javier Bardem.

Penélope Cruz Sánchez was born in Alcobendas, Community of Madrid, Spain, the daughter of Encarna Sánchez, a hairdresser and personal manager, and Eduardo Cruz, a retailer and auto mechanic. As a toddler, she was already a compulsive performer, re-enacting TV commercials for her family's amusement. Initially, Cruz focused on dance. After studying classical ballet for nine years at Spain's National Conservatory, she continued her training under a series of prominent dancers. She received three years of Spanish Ballet training with Ángela Garrido. She also had jazz dance training with Raúl Caballero and studied at Cristina Rota (mother of Juan Diego Botto) school in Madrid. At 15, however, she followed another calling after beating more than 300 other girls at a talent agency audition.

Cruz has a younger brother, Eduardo, a singer, and a younger sister, Mónica.
Cruz claims to have been a vegetarian since 2000. She speaks four languages: Spanish, Italian, French and English. Cruz has also donated a considerable amount of money and time to charity; in 1997 she volunteered in Uganda for two months.
Cruz was raised as a Roman Catholic, but now feels closest to Buddhism. After appearing in Vanilla Sky with Tom Cruise, they had a three-year relationship which ended in January 2004. During that time, she and Cruise were seen visiting several Church of Scientology locations in Hollywood, and there was published speculation that Cruise had convinced Cruz to join the church.

In April 2007 Cruz, who was single at the time, stated that she would like to have children one day and she feels the need to adopt. "Of course I want to have kids," Cruz, told the Spanish edition of Marie Claire in its April issue. "I want to have my own kids, but also adopt. For a while I've had the feeling that my life won't be complete if I don't adopt".